/ Dictionary / Index O open sesame: Meaning and Definition of Find definitions for: o'pen ses'ame Pronunciation: [key] any marvelously effective means for bringing about a desired result: Wealth is the open sesame to happiness. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. open sentence open-shelf Related Content Daily Word Quiz: longevity Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language