/ Dictionary / Index O opioid: Meaning and Definition of Find definitions for: o•pi•oid Pronunciation: (ō'pē-oid"), [key] — n. Biochem, Pharm. any opiumlike substance. any of a group of natural substances, as the endorphins, produced by the body in increased amounts in response to stress and pain. any of several synthetic compounds, as methadone, having effects similar to natural opium alkaloids and their derivatives. —adj. pertaining to such a substance. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. opinioned opistho- Related Content Daily Word Quiz: secular Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language