/ Dictionary / Index O original sin: Meaning and Definition of Find definitions for: orig'inal sin' Pronunciation: [key] a depravity, or tendency to evil, held to be innate in humankind and transmitted from Adam to the race in consequence of his sin. inclination to evil, inherent in human nature. the privation of sanctifying grace in consequence of the sin of Adam. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. originally originate Related Content Daily Word Quiz: penchant Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language