/ Dictionary / Index O orthopnea: Meaning and Definition of Find definitions for: or•thop•ne•a Pronunciation: (ôr-thop'nē-u, ôr"thop-nē'u, -thup-), [key] — n. Path. difficult or painful breathing except in an erect sitting or standing position. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: orthopnea (Thesaurus) orthophyric orthopod Related Content Daily Word Quiz: bungled Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language