/ Dictionary / Index P painkiller: Meaning and Definition of Find definitions for: pain•kill•er Pronunciation: (pān'kil"ur), [key] a drug, treatment, or anything else that relieves pain, esp. an analgesic. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: painkiller (Thesaurus) painful painless Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language