/ Dictionary / Index P Pius II: Meaning and Definition of Find definitions for: Pius II Pronunciation: [key] (Enea Silvio de Piccolomini) 1405–64, Italian ecclesiastic: pope 1458–64. Literary name, Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Pius I Pius III Related Content Daily Word Quiz: eureka Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language