/ Dictionary / Index P poisonous: Meaning and Definition of Find definitions for: poi•son•ous Pronunciation: (poi'zu-nus), [key] — adj. full of or containing poison: poisonous air; a poisonous substance. harmful; destructive: poisonous to animals; poisonous rumors. deeply malicious; malevolent: poisonous efforts. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: poisonous (Thesaurus) poison oak poison-pen Related Content Daily Word Quiz: rustic Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language