/ Dictionary / Index P polyalphabetic substitution: Meaning and Definition of Find definitions for: pol'y•al•pha•bet'ic substitu'tion Pronunciation: (pol'ē-al"fu-bet'ik, pol"ē-), [key] — Cryptography. Cryptography. a system of substitution that mixes together a number of cipher alphabets in a cryptogram so that each plaintext letter is represented by a cipher that repeatedly changes. Cf. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. polyalcohol polyamide Related Content Daily Word Quiz: modify Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language