/ Dictionary / Index P Port St. Lucie: Meaning and Definition of Find definitions for: Port St. Lu•cie Pronunciation: (l'sē), [key] a town in E Florida. 14,690. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Portsmouth Port Sudan Related Content Daily Word Quiz: eureka Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language