/ Dictionary / Index P Potomac: Meaning and Definition of Find definitions for: Po•to•mac Pronunciation: (pu-tō'muk), [key] — n. a river flowing SE from the Allegheny Mountains in West Virginia, along the boundary between Maryland and Virginia to the Chesapeake Bay. 287 mi. (460 km) long. a city in central Maryland, near Washington, D.C. 40,402. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: potomac (Thesaurus) pot of gold Potomac fever Related Content Daily Word Quiz: endear Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language