/ Dictionary / Index P predisposition: Meaning and Definition of Find definitions for: pre•dis•po•si•tion Pronunciation: (prē-dis"pu-zish'un, prē"dis-), [key] — n. the fact or condition of being predisposed: a predisposition to think optimistically. tendency to a condition or quality, usually based on the combined effects of genetic and environmental factors. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: predisposition (Thesaurus) predispose predistortion Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language