/ Dictionary / Index P puffer: Meaning and Definition of Find definitions for: puff•er Pronunciation: (puf'ur), [key] — n. a person or thing that puffs. Also calledany of various fishes of the family Tetraodontidae, capable of inflating the body with water or air until it resembles a globe, the spines in the skin becoming erected: several species contain the potent nerve poison tetrodotoxin. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: puffer (Thesaurus) puffbird puffery Related Content Daily Word Quiz: exemplary Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language