/ Dictionary / Index P pythoness: Meaning and Definition of Find definitions for: py•tho•ness Pronunciation: (pī'thu-nis, pith'u-), [key] — n. a woman believed to be possessed by a soothsaying spirit, as the priestess of Apollo at Delphi. a woman who practices divination. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: pythoness (Thesaurus) python pythonic Related Content Daily Word Quiz: opulent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language