/ Dictionary / Index R Roanoke: Meaning and Definition of Find definitions for: Ro•a•noke Pronunciation: (rō'u-nōk"), [key] — n. a city in SW Virginia. 100,427. a river flowing SE from western Virginia to Albemarle Sound in North Carolina. 380 mi. (610 km) long. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: roanoke (Thesaurus) roan Roanoke bells Related Content Daily Word Quiz: placid Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language