/ Dictionary / Index S Sacajawea: Meaning and Definition of Find definitions for: Sac•a•ja•we•a Pronunciation: (sak"u-ju-wē'u), [key] — n. 1787?–1812?, Shoshone guide and interpreter: accompanied Lewis and Clark expedition 1804–05. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: sacajawea (Thesaurus) sac sac-a-lait Related Content Daily Word Quiz: endear Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language