/ Dictionary / Index S San Francisco: Meaning and Definition of Find definitions for: San Fran•cis•co Pronunciation: (san" frun-sis'kō, fran-), [key] a seaport in W California, on San Francisco Bay: earthquake and fire 1906; United Nations Conference 1945. 678,974. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Sanforized San Francisco Bay Related Content Daily Word Quiz: supine Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language