/ Dictionary / Index S scleroderma: Meaning and Definition of Find definitions for: scle•ro•der•ma Pronunciation: (sklēr"u-dûr'mu, skler"-), [key] — n. Pathol. a disease in which connective tissue anywhere in the body becomes hardened and rigid. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: scleroderma (Thesaurus) sclero- sclerodermatous Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language