/ Dictionary / Index S sclerosis: Meaning and Definition of Find definitions for: scle•ro•sis Pronunciation: (skli-rō'sis), [key] — pl. -ses a hardening or induration of a tissue or part, or an increase of connective tissue or the like at the expense of more active tissue. a hardening of a tissue or cell wall by thickening or lignification. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: sclerosis (Thesaurus) sclerosed sclerotherapy Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language