/ Dictionary / Index S screwup: Meaning and Definition of Find definitions for: screw•up Pronunciation: (skr'up"), [key] — n. Slang. a mistake or blunder: The package was delayed through an addressing screwup. a habitual blunderer. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: screwup (Thesaurus) screw-top screwworm Related Content Daily Word Quiz: crutiny Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language