/ Dictionary / Index S sex change: Meaning and Definition of Find definitions for: sex' change" Pronunciation: [key] the alteration, by surgery and hormone treatments, of a person's morphological sex characteristics to approximate those of the opposite sex. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. sexcentenary sex chromatin Related Content Daily Word Quiz: acquiesce Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language