/ Dictionary / Index S sexual orientation: Meaning and Definition of Find definitions for: sex'ual orienta'tion Pronunciation: [key] one's natural preference in sexual partners; predilection for homosexuality, heterosexuality, or bisexuality. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. sexually transmitted disease sexual relations Related Content Daily Word Quiz: fidelity Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language