/ Dictionary / Index S shake-up: Meaning and Definition of Find definitions for: shake-up Pronunciation: (shāk'up"), [key] — n. a thorough change in a business, department, or the like, as by dismissals, demotions, etc. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: shake-up (Thesaurus) Shakespearean sonnet Shakhty Related Content Daily Word Quiz: menagerie Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language