/ Dictionary / Index S sissy: Meaning and Definition of Find definitions for: sis•sy Pronunciation: (sis'ē), [key] — n., pl. adj. -sies, —n. an effeminate boy or man. a timid or cowardly person. a little girl. —adj. of, pertaining to, or characteristic of a sissy. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: sissy (Thesaurus) sissonne sissy bar Related Content Daily Word Quiz: endear Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language