/ Dictionary / Index S Sixtus II: Meaning and Definition of Find definitions for: Sixtus II Pronunciation: [key] died a.d.258, pope 257–258. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Sixtus I Sixtus III Related Content Daily Word Quiz: neologism Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language