/ Dictionary / Index S smallpox: Meaning and Definition of Find definitions for: small•pox Pronunciation: (smôl'poks"), [key] — n. Pathol. an acute, highly contagious, febrile disease, caused by the variola virus, and characterized by a pustular eruption that often leaves permanent pits or scars: eradicated worldwide by vaccination programs. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: smallpox (Thesaurus) small potatoes small print Related Content Daily Word Quiz: eureka Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language