/ Dictionary / Index S softening of the brain: Meaning and Definition of Find definitions for: soft'ening of the brain' Pronunciation: [key] — Pathol. Pathol. a softening of the cerebrum, caused by impairment of the blood supply; encephalomalacia. dementia associated with general paresis. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. soft energy soft-finned Related Content Daily Word Quiz: hedonist Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language