/ Dictionary / Index S spironolactone: Meaning and Definition of Find definitions for: spi•ro•no•lac•tone Pronunciation: (spī"ru-nō-lak'tōn, spī-rō"-, -ron"u-), [key] — n. Pharm. a steroid, CHOS, used in combination with other drugs as a diuretic and antihypertensive. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: spironolactone (Thesaurus) spirometer spirt Related Content Daily Word Quiz: acquiesce Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language