/ Dictionary / Index S SSPE: Meaning and Definition of Find definitions for: SSPE Pronunciation: [key] subacute sclerosing panencephalitis. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: sspe (Thesaurus) SSN SSR Related Content Daily Word Quiz: arboreal Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language