/ Dictionary / Index S substrate: Meaning and Definition of Find definitions for: sub•strate Pronunciation: (sub'strāt), [key] — n. a substratum. the substance acted upon by an enzyme. a supporting material on which a circuit is formed or fabricated. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: substrate (Thesaurus) substitutive substratosphere Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language