/ Dictionary / Index S Syracuse: Meaning and Definition of Find definitions for: Syr•a•cuse Pronunciation: (sir'u-kys", -kyz"), [key] — n. a city in central New York. 170,105. Italian,a seaport in SE Sicily: ancient city founded by the Carthaginians 734b.c.; battles 413b.c.,212b.c.121,134. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: syracuse (Thesaurus) Syr. Syr Darya Related Content Daily Word Quiz: eureka Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language