/ Dictionary / Index S systemic lupus erythematosus: Meaning and Definition of Find definitions for: system'ic lu'pus erythemato'sus Pronunciation: [key] — Pathol. Pathol. an autoimmune inflammatory disease of the connective tissues, occurring mainly among middle-aged women, chiefly characterized by skin eruptions, joint pain, recurrent pleurisy, and kidney disease. Abbr.: SLE Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. systemic linguistics systemize Related Content Daily Word Quiz: paradox Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language