/ Dictionary / Index S systole: Meaning and Definition of Find definitions for: sys•to•le Pronunciation: (sis'tu-lē", -lē), [key] — n. the normal rhythmical contraction of the heart, during which the blood in the chambers is forced onward. Cf. the shortening of a syllable regularly long. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: systole (Thesaurus) systems software systolic Related Content Daily Word Quiz: pudgy Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language