/ Dictionary / Index T Tay-Sachs disease: Meaning and Definition of Find definitions for: Tay'-Sachs' disease" Pronunciation: (tā'saks'), [key] — Pathol. Pathol. a rare fatal hereditary disease, occurring chiefly in infants and children, esp. of eastern European Jewish origin, characterized by a red spot on the retina, gradual blindness, and paralysis. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. tayra Tayside Related Content Daily Word Quiz: simian Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language