/ Dictionary / Index T tolbutamide: Meaning and Definition of Find definitions for: tol•bu•ta•mide Pronunciation: (tol-by'tu-mīd"), [key] — n. Pharm. a white crystalline substance, CHNOS, used to augment insulin secretion in the treatment of diabetes mellitus. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: tolbutamide (Thesaurus) tolbooth told Related Content Daily Word Quiz: panacea Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language