/ Dictionary / Index T trisomy: Meaning and Definition of Find definitions for: tri•so•my Pronunciation: (trī'sō-mē), [key] — n. Pathol. an abnormality characterized by the presence of an additional chromosome to the normal diploid number. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: trisomy (Thesaurus) trisomic trisomy 21 Related Content Daily Word Quiz: placid Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language