/ Dictionary / Index U urethrostomy: Meaning and Definition of Find definitions for: u•re•thros•to•my Pronunciation: (yoor"u-thros'tu-mē), [key] — pl. -mies. the construction of an artificial opening from the urethra through the perineum, permitting the passage of urine. the opening so constructed. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. urethroscopy urethrotomy Related Content Daily Word Quiz: tactful Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language