/ Dictionary / Index Z zygotene: Meaning and Definition of Find definitions for: zy•go•tene Pronunciation: (zī'gu-tēn", zig'u-), [key] — n. Cell Biol. the second stage of prophase in meiosis, during which strands of homologous chromosomes line up and become pairs. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: zygotene (Thesaurus) zygote zygotic Related Content Daily Word Quiz: tactful Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language