| First Round—Cleveland | North Carolina 75, UC-Riverside 51 |
| Vanderbilt 76, Louisville 64 |
| UCLA 74, Bowling Green 61 |
| Purdue 73, Missouri State 52 |
| Texas A&M 65, Texas Christian 69 |
| Rutgers 63, Dartmouth 58 |
| George Washington 87, Old Dominion 72 |
| Tennessee 102, Army 54 |
| |
| First Round—Albuquerque | Ohio State 68, Oakland 45 |
| Boston College 78, Notre Dame 61 |
| Utah 76, Middle Tennessee |
| Arizona State 80, S. F. Austin 61 |
| Florida 59, New Mexico 83 |
| Baylor 74, Northern Arizona 56 |
| St. John's (NY) 78, California 68 |
| Maryland 95, Sacred Heart 54 |
| First Round—Bridgeport | Duke 96, Southern 27 |
| Southern California 67, South Florida 65 |
| Kentucky 69, Chattanooga 59 |
| Michigan State 65, Wisconsin-Milwaukee 46 |
| Temple 58, Hartford 64 |
| George 75, Maris 60 |
| Virginia Tech 82, Missouri 51 |
| Connecticut 77, Coppin State 54 |
| First Round—San Antonio | Louisiana State 72, Florida Atlantic 48 |
| minnesota 69, Washington 73 |
| North Carolina State 61, Tulsa 71 |
| DePaul 68, Liberty 43 |
| Florida State 80, Louisiana Tech 71 |
| Stanford 72, SE Missouri State 45 |
| Brigham Young 67, Iowa 62 |
| Oklahoma 78, Pepperdine 66 |
| Second Round—Cleveland | North Carolina 89, Vanderbilt 70 |
| UCLA 54, Purdue 61 |
| Texas Christian 48, Rutgers 82 |
| George Washington 53, Tennessee 66 |
| Second Round—Albuquerque | Ohio State 69, Boston College 79 |
| Utah 86, Arizona State 65 |
| New Mexico 67, Baylor 87 |
| St. John's (NY) 74, Maryland 81 |
| Second Round—Bridgeport | Duke 85, Southern California 51 |
| Kentucky 63, Michigan State 67 |
| Hartford 54, Georgia 73 |
| Virginia Tech 56, Connecticut 79 |
| Second Round—San Antonio | Louisiana State 72, Washington 49 |
| Tulsa 67, DePaul 71 |
| Florida State 70, Stanford 88 |
| Brigham Young 70, Oklahoma 86 |
| Third Round—Cleveland | North Carolina 70, Purdue 68 |
| Rutgers 69, Tennessee 76 |
| Third Round—Albuquerque | Boston College 54, Utah 57 |
| Baylor 63, Maryland 82 |
| Third Round—Bridgeport | Duke 86, Michigan State 61 |
| Georgia 75, Connecticut 77 |
| Third Round—San Antonio | Louisiana State 66, DePaul 56 |
| Stanford 88, Oklahoma 74 |
| Regional Finals | Cleveland—North Carolina 75, Tennessee 63 |
| Albuquerque—Utah 65, Maryland 75 |
| Bridgeport—Duke 63, Connecticut 61 |
| San Antonio—Louisiana State 62, Stanford 59 |
| Final Four | (April 2, 2006, Boston, Mass.) |
| North Carolina 70, Maryland 81 |
| Duke 64, Louisiana State 45 |
| National Championship | (April 4, 2006, Boston, Mass.) |
| Maryland 78, Duke 75 |
