/ Thesaurus / I Synonyms of in and of itself Find synonyms for: Adverb1. intrinsically, per se, as such, in and of itselfusage: with respect to its inherent nature; "this statement is interesting per se"WordNet 3.0 Copyright © 2006 by Princeton University. All rights reserved. Related Content Daily Word Quiz: spectral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language