/ Dictionary / Index A afflict: Meaning and Definition of Find definitions for: af•flict Pronunciation: (u-flikt'), [key] — v.t. to distress with mental or bodily pain; trouble greatly or grievously: to be afflicted with arthritis. to overthrow; defeat. to humble. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: afflict (Thesaurus) afflatus affliction Related Content Daily Word Quiz: immense Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language