/ Dictionary / Index A affliction: Meaning and Definition of Find definitions for: af•flic•tion Pronunciation: (u-flik'shun), [key] — n. a state of pain, distress, or grief; misery: They sympathized with us in our affliction. a cause of mental or bodily pain, as sickness, loss, calamity, or persecution. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: affliction (Thesaurus) afflict afflictive Related Content Daily Word Quiz: immense Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language