/ Dictionary / Index A antagonist: Meaning and Definition of Find definitions for: an•tag•o•nist Pronunciation: (an-tag'u-nist), [key] — n. a person who is opposed to, struggles against, or competes with another; opponent; adversary. the adversary of the hero or protagonist of a drama or other literary work: Iago is the antagonist of Othello. a muscle that acts in opposition to another. Cf. agonist (def. 3). a tooth in one jaw that articulates during mastication or occlusion with a tooth in the opposing jaw. a drug that counteracts the effects of another drug. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: antagonist (Thesaurus) antagonism antagonistic Related Content Daily Word Quiz: pundit Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language