/ Dictionary / Index A antagonistic: Meaning and Definition of Find definitions for: an•tag•o•nis•tic Pronunciation: (an-tag"u-nis'tik), [key] — adj. acting in opposition; opposing, esp. mutually. hostile; unfriendly. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: antagonistic (Thesaurus) antagonist antagonize Related Content Daily Word Quiz: pundit Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language