/ Dictionary / Index D defame: Meaning and Definition of Find definitions for: de•fame Pronunciation: (di-fām'), [key] — -famed, -fam•ing. to attack the good name or reputation of, as by uttering or publishing maliciously or falsely anything injurious; slander or libel; calumniate: The newspaper editorial defamed the politician. to disgrace; bring dishonor upon. to accuse. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: defame (Thesaurus) defamatory defang Related Content Daily Word Quiz: soporific Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language