/ Dictionary / Index D defang: Meaning and Definition of Find definitions for: de•fang Pronunciation: (dē-fang'), [key] — v.t. to remove the fangs of: to defang a snake. to cause to become less powerful or threatening; render harmless. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: defang (Thesaurus) defame default Related Content Daily Word Quiz: nonchalant Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language