/ Dictionary / Index D defuse: Meaning and Definition of Find definitions for: de•fuse Pronunciation: (dē-fyz'), [key] — v., -fused, -fus•ing. —v.t. to remove the fuze from (a bomb, mine, etc.). to make less dangerous, tense, or embarrassing: to defuse a potentially ugly situation. —v.i. to grow less dangerous; weaken. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: defuse (Thesaurus) defund defusion Related Content Daily Word Quiz: morose Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language