/ Dictionary / Index D depress: Meaning and Definition of Find definitions for: de•press Pronunciation: (di-pres'), [key] — v.t. to make sad or gloomy; lower in spirits; deject; dispirit. to lower in force, vigor, activity, etc.; weaken; make dull. to lower in amount or value. to put into a lower position: to depress the muzzle of a gun. to press down. to lower in pitch. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: depress (Thesaurus) depredation depressant Related Content Daily Word Quiz: impetuous Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language