/ Dictionary / Index D despise: Meaning and Definition of Find definitions for: de•spise Pronunciation: (di-spīz'), [key] — -spised, -spis•ing. to regard with contempt, distaste, disgust, or disdain; scorn; loathe. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: despise (Thesaurus) despicable despite Related Content Daily Word Quiz: soporific Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language