/ Dictionary / Index D despite: Meaning and Definition of Find definitions for: de•spite Pronunciation: (di-spīt'), [key] — prep., n., v., -spit•ed, -spit•ing. —prep. in spite of; notwithstanding. —n. contemptuous treatment; insult. malice, hatred, or spite. in spite of; notwithstanding: He was tolerant in despite of his background and education. —v.t. to anger or annoy (someone) out of spite. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: despite (Thesaurus) despise despiteful Related Content Daily Word Quiz: nonchalant Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language