/ Dictionary / Index D despiteful: Meaning and Definition of Find definitions for: de•spite•ful Pronunciation: (di-spīt'ful), [key] — adj. malicious; spiteful. contemptuous; insolent. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: despiteful (Thesaurus) despite despiteous Related Content Daily Word Quiz: clairvoyant Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language